Long-term metabolic consequences of acute dioxin exposure differ between male and female mice
Long-term metabolic consequences of acute dioxin exposure differ between male and female mice
SUMMARY Exposure to environmental pollutants is consistently associated with increased diabetes risk in humans. In male mice, acute dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin; TCDD) exposure supresses insulin secretion. This study investigated the long-term effects of a single TCDD injection (20 μg/kg) on glucose metabolism and beta cell function in male and female mice. TCDD-exposed males displayed modest fasting hypoglycemia for ～4 weeks post-injection, reduced fasting insulin levels for up to 6 weeks, increased insulin sensitivity, and decreased beta cell area. TCDD-exposed females also had long-term suppressed basal plasma insulin levels, and abnormal insulin secretion for up to 6 weeks. Unlike males, TCDD did not impact insulin sensitivity or beta cell area in females, but did cause transient glucose intolerance 4 weeks post-exposure. Our results show that a single exposure to dioxin can supress basal insulin levels long-term in both sexes, but effects on metabolism are sex-dependent.
Ibrahim Muna、Elsawy Mariam、Prakash Arina、Matteo Geronimo、Rick Kayleigh RC、Blair Hannah、Bruin Jennifer E、Solanki Shivani、O?ˉDwyer Shannon、Hoyeck Myriam P
Laboratory of Molecular and Cellular Medicine, Department of Cellular & Physiological Sciences, Life Sciences Institute, University of British ColumbiaDepartment of Biology & Institute of Biochemistry, Carleton UniversityDepartment of Biology & Institute of Biochemistry, Carleton UniversityDepartment of Biology & Institute of Biochemistry, Carleton UniversityDepartment of Biology & Institute of Biochemistry, Carleton UniversityDepartment of Biology & Institute of Biochemistry, Carleton UniversityDepartment of Biology & Institute of Biochemistry, Carleton UniversityDepartment of Biology & Institute of Biochemistry, Carleton UniversityLaboratory of Molecular and Cellular Medicine, Department of Cellular & Physiological Sciences, Life Sciences Institute, University of British ColumbiaDepartment of Biology & Institute of Biochemistry, Carleton University
医学研究方法基础医学环境污染、环境污染防治
diabetesinsulinpollutiondioxintoxicologybeta cellssex differences
Ibrahim Muna,Elsawy Mariam,Prakash Arina,Matteo Geronimo,Rick Kayleigh RC,Blair Hannah,Bruin Jennifer E,Solanki Shivani,O?ˉDwyer Shannon,Hoyeck Myriam P.Long-term metabolic consequences of acute dioxin exposure differ between male and female mice[EB/OL].(2025-03-28)[2025-06-14].https://www.biorxiv.org/content/10.1101/762476.点此复制
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