EVALUATION OF TAURINE’S NEUROPROTECTIVE EFFECTS ON SH-SY5Y CELLS UNDER OXIDATIVE STRESS
EVALUATION OF TAURINE’S NEUROPROTECTIVE EFFECTS ON SH-SY5Y CELLS UNDER OXIDATIVE STRESS
ABSTRACT Alzheimer’s disease (AD) is a type of dementia that affects millions of people. Although there is no cure, several study strategies seek to elucidate the mechanisms of the disease. Recent studies address the benefits of taurine. Thus, the present study aims to analyze the neuroprotective effect of taurine on human neuroblastoma, using an in vitro experimental model of oxidative stress induced by hydrocortisone in the SH-SY5Y cell line as a characteristic model of AD. The violet crystal assay was used for cell viability and the evaluation of cell morphology was performed by scanning electron microscopy (SEM). After pretreatment with taurine, the SH-SY5Y cell showed an improvement in cell viability in the face of oxidative stress and improved cell morphology. Thus, the treatment presented a neuroprotective effect. GRAPHICAL ABSTRACTbiorxiv;2021.04.26.441504v1/UFIG1F1ufig1
Salles Geisa Nogueira、Granato Alessandro Eustaquio Campos、de Oliveira Moraes Carlos Dailton Guedes、Soares Cristina Pacheco、Pinto Jessica Cristina、Rossato Rafaella Carvalho
Universidade do Vale do Paraiba (UNIVAP)Universidade de Sao PauloUniversidade do Vale do Paraiba (UNIVAP)Universidade do Vale do ParaibaUniversidade do Vale do Paraiba (UNIVAP)Universidade do Vale do Paraiba (UNIVAP)
神经病学、精神病学基础医学细胞生物学
Alzheimer’s DiseaseNeurodegenerative DiseaseOxidative StressTaurine
Salles Geisa Nogueira,Granato Alessandro Eustaquio Campos,de Oliveira Moraes Carlos Dailton Guedes,Soares Cristina Pacheco,Pinto Jessica Cristina,Rossato Rafaella Carvalho.EVALUATION OF TAURINE’S NEUROPROTECTIVE EFFECTS ON SH-SY5Y CELLS UNDER OXIDATIVE STRESS[EB/OL].(2025-03-28)[2025-06-03].https://www.biorxiv.org/content/10.1101/2021.04.26.441504.点此复制
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