2-(E)-亚苄基-5-芳氨基甲基环戊醇类化合物的合成及抗炎活性研究
Synthesis and anti-inflammatory activity of 2-(E)-benzylidene-5-arylaminomethylcyclopentanols
设计合成2-(E)-亚苄基-5-芳氨基甲基环戊醇类化合物,并对其抗炎活性进行初步的评价。以环戊酮为起始原料,通过Stork烯胺反应、Mannich反应、胺交换反应和选择性还原制备目标化合物;并以二甲苯致小鼠耳肿胀模型测试目标化合物的抗炎活性。共合成了16个新化合物,经1H-NMR、MS和IR确证结构。初步药理实验结果显示4个目标化合物具有较强的抗炎活性。
2-(E)-benzylidene-5-aminomethylcyclopentanols were synthesized and their anti-inflammatory activity was studied. The target compounds were synthesized from cyclopentanone via Stork reaction, Mannich reaction, amine exchange reaction and selective reduction. Xylene-induced mice ear edema assay was used to evaluate the anti-inflammatory activity of the target compounds. Sixteen novel compounds were synthesized and characterized using 1H-NMR, MS and IR. Preliminary pharmacological test showed that four compounds possessed potent anti-inflammatory activity.
邵太丽、于志瀛、徐莉英、马娟、董金华、滕伟
药学生物化学基础医学
Mannich碱2-(E)-亚苄基-5-芳氨基甲基环戊醇选择性还原抗炎活性
Mannich base 2-benzylidene-5-arylaminomethylcyclopentanol selective reduction anti-inflammatory activity
邵太丽,于志瀛,徐莉英,马娟,董金华,滕伟.2-(E)-亚苄基-5-芳氨基甲基环戊醇类化合物的合成及抗炎活性研究[EB/OL].(2007-12-19)[2025-08-23].http://www.paper.edu.cn/releasepaper/content/200712-448.点此复制
评论