卵巢切除治疗乳腺癌的系统评价

Objective To evaluate the treatment of breast cancer, ovarian removal efficacy and safety. Methods We searched the Chinese Journal Full-text database (1994-2010.4), Chinese Biomedical Literature Database (1978-2010.4), Chinese science and technology periodicals database (1989-2010.4) MEDLINE (1966-2010.4) and EMBASE (1974-2010.4) and received literature references, supplemented by manual search. Screening of all applications oophorectomy breast cancer randomized controlled trials (RCT). By the two independent quality assessment and data extraction, statistical analysis software. Results A total of seven studies, Meta analysis showed that: The overall survival rate higher than the treatment group [RR 1.04 95% Cl (0.98 1.11)]. Side effects, both studies vaginal dryness [RR 1.06 95% Cl (0.97 1.06)], the differences were statistically significant, but heterogeneous higher (P <0.0001, I2 = 98.4%),; stomatitis and diarrhea the occurrence of the treatment group were lower than the control group; conclusions of existing clinical evidence that ovariectomy on the quality of life of patients with breast cancer has improved, but in view of its side effects, evaluation of long-term survival rate (15 years and 20 years) in patients Test a small, yet can not make definite conclusions whether an effective, need more high quality randomized controlled trials and longer follow-up further confirmed.