An agnostic study of associations between ABO and RhD blood group and phenome-wide disease risk
An agnostic study of associations between ABO and RhD blood group and phenome-wide disease risk
Abstract There are multiple known associations between the ABO and RhD blood groups and disease. However, no systematic population-based studies elucidating associations between a large number of disease states and blood group have been conducted. Using SCANDAT3-S, a comprehensive nationwide blood donation-transfusion database, we modelled outcomes for 1,217 disease categories including 70 million person-years of follow-up, accruing from 5.1 million unique individuals. We discovered 49 and 1 associations between a disease and ABO and RhD blood group, respectively, after adjustment for multiple testing. We identified new associations such as kidney stones and blood group B as compared to O. We also expanded previous knowledge on other associations such as pregnancy-induced hypertension and blood group A and AB as compared to O and RhD positive as compared to negative. Our findings generate strong further support for previously known associations, but also indicate new interesting relations.
Olsson Martin L、Edgren Gustaf、Zhao Jingcheng、Clements Mark、Dahl¨|n Torsten
Division of Hematology and Transfusion Medicine, Department of Laboratory Medicine, Lund University & Department of Clinical Immunology and Transfusion Medicine, Office of Medical ServicesDepartment of Medicine Solna, Clinical Epidemiology Division, Karolinska Institutet||Cardiology Department, S?dersjukhusetDepartment of Medicine Solna, Clinical Epidemiology Division, Karolinska InstitutetDepartment of Medical Epidemiology and Biostatistics, Karolinska InstitutetDepartment of Medicine Solna, Clinical Epidemiology Division, Karolinska Institutet||Hematology Department, Karolinska University Hospital
医学研究方法基础医学医药卫生理论
ABORhDdisease occurrenceagnosticphenome-wide study
Olsson Martin L,Edgren Gustaf,Zhao Jingcheng,Clements Mark,Dahl¨|n Torsten.An agnostic study of associations between ABO and RhD blood group and phenome-wide disease risk[EB/OL].(2025-03-28)[2025-05-12].https://www.biorxiv.org/content/10.1101/2021.01.28.428569.点此复制
评论