Systems Biology Approach of Understanding Insulin Resistance: Linkage between Type 2 Diabetes & Alzheimer’s Disease
Systems Biology Approach of Understanding Insulin Resistance: Linkage between Type 2 Diabetes & Alzheimer’s Disease
ABSTRACT Insulin resistance (IR) is a physiological condition in which cells in the body become resistant to insulin. It is a known risk factor associated to type 2 diabetes (T2D). Recently, the idea that IR plays an important role in the progression of Alzheimer’s disease (AD) has been gaining a lot of attention. Comparing the components of the insulin signalling pathway in relation to T2D and AD, there seems to be a lot of commonality. However, on what role IR plays in linking T2D and AD remains unknown. Through systems biology approach, we extended an existing mathematical model (i.e. ODE based) to study and understand the role IR plays in linking T2D and AD. The simulations, together with the experimental data collected from the literature, show that the common components in T2D and AD express the same dynamical behaviors. This result provides the bases for further modelling of the insulin signaling pathway in determining the link between T2D and AD.
Villasis Osbert Bryan、Tan Daniel Stanley、Mendoza Eduardo、Lao Angelyn
Department of Mathematics & Statistics, De La Salle University||Senior High School, University of Santo TomasResearch Center for Information Technology, Academia SinicaDepartment of Mathematics & Statistics, De La Salle University||Max Planck Institute of Biochemistry||Faculty of Physics, Ludwig Maximilian University||Systems and Computational Biology Research Unit, Center for Natural Sciences and Environmental ResearchDepartment of Mathematics & Statistics, De La Salle University||Systems and Computational Biology Research Unit, Center for Natural Sciences and Environmental Research||Center for Complexity and Emerging Technologies
医药卫生理论医学研究方法基础医学神经病学、精神病学
Insulin ResistanceType 2 diabetesAlzheimer’s diseasemathematical modeling
Villasis Osbert Bryan,Tan Daniel Stanley,Mendoza Eduardo,Lao Angelyn.Systems Biology Approach of Understanding Insulin Resistance: Linkage between Type 2 Diabetes & Alzheimer’s Disease[EB/OL].(2025-03-28)[2025-04-24].https://www.biorxiv.org/content/10.1101/2022.04.13.463890.点此复制
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