葛斛调脂方干预代谢综合征患者的随机对照研究
Randomized Controlled Study on Gehu Tiaozhi Decoction Intervening Patients with Metabolic Syndrome ZHENG
郑蓉，刘志栋，王淼，张笑，陈俊岚，周时高 *
作者信息
摘要
背景 全球约有 1/4 的人患有代谢综合征（MetS）。近年来我国 MetS 患病率也呈逐年上升趋势，对生命健康造成严重威胁。中医药治疗 MetS 有着多靶点、多环节的优势，但目前临床上缺乏高质量的随机对照研究和真实世界研究。 目的 观察葛斛调脂方（葛根 6 g，铁皮石斛 6 g）对 MetS 患者腰围、体质量、体脂率及糖脂代谢的影响。 方法 2021 年 6 月至 2022 年 11 月前瞻性选取上海中医药大学附属龙华医院门诊就诊及住院的 84 例 MetS 患者为研究对象。应用 SPSS 25.0 统计软件给定随机种子数，将受试者随机分为葛斛组（42 例）和对照组（42 例）。葛斛组应用葛斛调脂方颗粒治疗（葛根 6 g，铁皮石斛 6 g），患者空腹早晚各 1 次，1 包 / 次，冲服，连续服用 8 周。对照组应用安慰剂颗粒干预，患者空腹早晚各 1 次，1 包 / 次，连续服用 8 周。干预期间对两组患者进行相同的健康宣教（包括膳食方案和运动处方的指导）。干预 8周后对比分析两组患者的腰围（WC）、体质量、体质指数（BMI）、体脂率（BFP）、三酰甘油（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、空腹血糖（FBG）。 结果 最终葛斛组 41 例、对照组 41 例完成 8 周的干预研究。治疗前两组患者 WC、体质量、BMI、BFP 比较，差异均无统计学意义（ P>0.05）。两组治疗前后 WC、体质量、BMI、BFP 差值比较，差异均有统计学意义（ P0.05）。两组治疗前后 TG、TC、FBG 差值比较，差异均有统计学意义（ P<0.05）。 结论 葛斛调脂方能较好地改善 MetS 患者的 WC、体质量、BMI、BFP、TG、TC 及 FBG，且安全性较好。
Abstract
BackgroundAbout a quarter of the world's population suffers from metabolic syndrome MetS.In recent yearsthe prevalence of MetS in China has also increased year by yearposing a serious threat to life and health.Traditional chinese medicine has the advantages of multi-target and multi-link in the treatment of MetSbut there is a lack of high-quality randomized controlled studies and real-world studies in clinical practice. ObjectiveTo observe the effects of Gehu Tiaozhi Decoction Pueraria lobamle radix 6 gDendrobium officinale 6 g on waist circumferencebody weightbody fat rate and glucose and lipid metabolism in patients with MetS. MethodsFrom June 2021 to November 202284 patients with MetS were prospectively selected from the outpatient department and inpatient department of LongHua Hospital Shanghai University of Traditional Chinese Medicine. The subjects were randomly divided into Gehu group 42 cases and control group 42 cases.The patients in the Gehu group were treated with Gehu Tiaozhi DecoctionPueraria lobamle radix 6 gDendrobium officinale 6 g. The patients were fasted once in the morning and once in the evening1 bag each timetaken orally for 8 weeks. The control group was treated with placebo granules. The patients were fasted once in the morning and once in the evening1 bag each timefor 8 weeks. During the interventionthe two groups of patients were given the same health education including dietary regimen and exercise prescription guidance. After 8 weeks of interventionthe WCbody weightBMIBFPtriglyceridetotal cholesterolhigh density lipoprotein cholesterollow density lipoprotein cholesterol and fasting blood glucose were compared between the two groups. ResultsFinally41 patients in the Gehu group and 41 patients in the control group completed the 8-week intervention study. No statistically significant differences of WCbody weightBMI or BFP was found between the two groups before treatment P>0. 05.The differences of WCbody weightBMI and BFP between the two groups before and after treatment were statistically significant P0. 05. The differences of TGTC and FBG between the two groups before and after treatment were statistically significant P<0.05. Conclusion Gehu Tiaozhi Decoction can better improve the WCbody weightBMIBFPTGTC and FBG of MetS patientsand has good safety.关键词
代谢综合征/葛根/铁皮石斛/中医药学/临床研究引用本文复制引用
郑蓉，刘志栋，王淼，张笑，陈俊岚，周时高 *.葛斛调脂方干预代谢综合征患者的随机对照研究[EB/OL].(2023-04-03)[2026-04-03].https://chinaxiv.org/abs/202304.00908.学科分类
中医学/医学研究方法/内科学
评论