质子酸催化的氮杂芳烃苄位C-H键与亚硝基化合物的亲核加成反应研究
Br?nsted Acid Catalyzed Benzylic C–H Bond Functionalization of Azaarenes: Nucleophilic Addition to Nitroso Compounds
本文报道了实用的质子酸催化下2-烷基氮杂芳烃苄位C-H键与亚硝基化合物的亲核加成反应，反应在温和的条件下进行。通过加入不同的质子酸作为催化剂，这种方法可以选择性实现氮杂芳烃-2-亚胺、氮杂芳烃-2-甲醛或者氮杂芳烃-2-肟酸的合成。且反应无需金属催化剂，强碱、氧化剂或者其他任何添加剂，同时具有高产率、高底物普适性优点。
practical Br?nsted acid promoted benzylic C–H functionalization of 2-alkylazaarenes and nucleophilic addition to nitroso compounds was developed under mild conditions. Switched by Br?nsted acids, this method can afford azaarene-2-aldimines, azaarene-2-carbaldehyde or azaarene-2-oximes selectively. No metal, base, oxidant or other additives were required.
杨罗、高旭
有机化学工业精细化学工业
氮杂芳烃质子酸催化亚硝基化合物
azaareneBr?nsted acidnitroso compound
杨罗,高旭.质子酸催化的氮杂芳烃苄位C-H键与亚硝基化合物的亲核加成反应研究[EB/OL].(2014-06-30)[2025-08-16].http://www.paper.edu.cn/releasepaper/content/201406-462.点此复制
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