中药上感舒体内抗菌实验研究
Study on antibacterial effect of Shangganshu in infected mice body
目的：通过上感舒的体内抗菌实验，观察其抗菌作用，为其治疗上呼吸道感染性疾病提供实验依据。方法：金黄色葡萄球菌和肺炎链球菌分别培养18小时增殖后，用5%干酵母溶液稀释成不同浓度，分别对小鼠体内腹腔注射，选用80%~100%致死率的的金黄色葡萄球菌和肺炎链球菌的5%干酵母溶液，感染给药小鼠，观测给药小鼠在染菌后七天内的平均存活天数和死亡率。结果：中药上感舒的1g/kg、0.5g/kg、0.25g/kg剂量均能不同程度的抑制金黄色葡萄球菌和肺炎链球菌感染小鼠的死亡率并延长平均存活天数。结论：中药上感舒具有一定的体内抗菌作用，与临床治疗上呼吸道感染相符。
Objective: The antibacterial effect of Shangganshu in infected mice body was studied in order to provide experimental evidence for its clinical application. Methods: Staphylococcus aureus (SA) and Streptococcus pneumoniae (SP) were cultured for 18 hours, and then 5% yeast liquor was added each of them to a suitable level which made 80%~100% effected mice die. Then each of the suitable bacterial liquor were inocutated into the abdominal cauity of mice who had given corresponding medicines for 3 days. Death rate and average survival time were both observed within 7 days after effected. and analyzed. Results: Shangganshu high dose、middle dose and low dose all could depress the death rate and lengthen the average survival time of mice infected by SA and infected by SP. Conclusion: The 3 dose of Shangganshu have remarkable effect on mice infected by SA and SP, showing its some antibacterial effect in vivo.
李佳川、任志丽、王张 、缪舒益
医药卫生理论中医学医学研究方法
中药，体内抗菌，金黄色葡萄球菌，肺炎链球菌
traditional Chinese medicine，antibacterial effect in vivo，Staphylococcus aureus，Streptococcus pneumoniae
李佳川,任志丽,王张 ,缪舒益.中药上感舒体内抗菌实验研究[EB/OL].(2007-10-08)[2025-08-10].http://www.paper.edu.cn/releasepaper/content/200710-36.点此复制
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