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How to fold intricately: using theory and experiments to unravel the properties of knotted proteins

How to fold intricately: using theory and experiments to unravel the properties of knotted proteins

来源:Arxiv_logoArxiv
英文摘要

Over the years, advances in experimental and computational methods have helped us to understand the role of thermodynamic, kinetic and active (chaperone-aided) effects in coordinating the folding steps required to achieving a knotted native state. Here, we review such developments by paying particular attention to the complementarity of experimental and computational studies. Key open issues that could be tackled with either or both approaches are finally pointed out.

Antonio Suma、Cristian Micheletti、Sophie E. Jackson

10.1016/j.sbi.2016.10.002

生物科学研究方法、生物科学研究技术生物物理学

Antonio Suma,Cristian Micheletti,Sophie E. Jackson.How to fold intricately: using theory and experiments to unravel the properties of knotted proteins[EB/OL].(2016-10-18)[2025-08-02].https://arxiv.org/abs/1610.05779.点此复制

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