MMP-2、CXCR4和BMP-2在乳腺癌患者中的表达及其生物学意义

Objective：To investigate the expression and the biological significance of matrix metalloproteinase-2（MMP-2）、chemokines receptor CXCR4 and bone morphogenetic protein-2（BMP-2）in patients with breast cancer and analyze their correlation. Methods：A total of 103 breast cancer patients including 48 cases with lymph node metastasis were analysed. The expressions of MMP-2、CXCR4 and BMP-2 were detected by inmunohistochemical staining. The correlations among the expressions of MMP-2、CXCR4、BMP-2 and clinical stage，lymph node metastasis and tumor size were analysed. Results:The positive expression rates of MMP-2、CXCR4 and BMP-2 were 58.3%、91.7% and 58.3% in the group of breast cancer with lymph node metastasis, significantly higher than those in the group of breast cancer without lymph node metastasis which were 29.1%、70.9% and 38.2% ,respectively（P<0.05）;Positive correlation could be found between MMP-2 and CXCR4、BMP-2 expression（r=0.162，P<0.05；r=0.316，P<0.01）and also between CXCR4 and BMP-2 expression （r=0.271；P<0.05）. Conclusion：MMP-2、CXCR4 and BMP-2 are highly expressed in the group of breast cancer with lymph node metastasis. These results suggest that they might be important factors in breast metastasis. These proteins are indicators of metastasis of breast cancer.