EBV疫苗研究进展
he research progress of EBV vaccine
EB 病毒（Epstein-barr virus, EBV）属于γ-疱疹病毒家族，又称人类疱疹病毒4 型（HHV-4），于1964年由Epstein和Barr 首次从非洲儿童的burkitt 淋巴瘤细胞中分离得到。EBV感染很普遍，接近95%的人群曾经感染过EBV，大部分EBV感染发生在婴幼儿时期，并以潜伏感染的形式存在。在发达国家，超过50%的青少年未曾感染EBV，但这些EBV易感群体一旦感染EBV，就有50%的几率可能发生传染性单核细胞增多症（Infection Mononucleosis, IM）。除此之外EBV还与鼻咽癌(nasopharyngeal cancer, NPC)、Hodgkin's 淋巴瘤、Burkitt 淋巴瘤、胃癌、以及获得性免疫缺陷综合症（Acquired Immune Deficiency Syndrome, AIDS）患者的口腔毛状白斑症等发生发展密切相关。因此，开发EBV疫苗用于预防或治疗这些疾病具有极大的临床意义。
EBV belongs to the γ-herpes virus family, also called human herpesvirus 4 (HHV-4), which is founded and established by Epstein and Barr in 1964, for the first time isolated from an African child's burkitt lymphoma cells suspension culture. Nearly 95% of people have been infected with EBV. Most infections occur during early childhood and in the form of latent infections. However, in developed countries, up to 50% of adolescents and young adults have not yet been infected, and nearly 50% of these susceptible individuals may develop IM if infected with EBV.Besides, EBV is also closely related to the development of NPC, Hodgkin lymphoma, Burkitt lymphoma, gastric cancer, and AIDS patients with Oral Hairy Leukoplakia.These epidemiological data show that prevention and therapy of these diseases through EBV vaccination would have a great clinical significance.
李智、孙仑泉、刘丽愉、董留威
预防医学基础医学肿瘤学
EBV，预防性疫苗，治疗性疫苗
EBVprophylactic vaccinetherapeutic vaccine.
李智,孙仑泉,刘丽愉,董留威.EBV疫苗研究进展[EB/OL].(2016-11-08)[2025-04-27].http://www.paper.edu.cn/releasepaper/content/201611-105.点此复制
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