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解郁1号对抑郁模型大鼠海马神经元细胞凋亡的影响

Effect of Jieyue 1# on the Apoptosis of Hippocampus

中文摘要英文摘要

目的:探讨以调理脾胃气机法组成的中药复方解郁1号对抑郁模型大鼠海马神经细胞元凋亡的影响。方法:将60只SD大鼠随机分为正常组、模型组、西药组及中药组,每组15只,应用孤养加慢性轻度不可预见性应激方法复制大鼠抑郁症模型,采用Open-field法测定各组大鼠的行为变化;TUNEL法检测海马CA3区神经元细胞凋亡情况。结果:模型组大鼠水平活动及垂直活动得分显著减少(P<0.01),海马CA3区内凋亡细胞数显著增加(P<0.01)。与模型组比较,中、西药组大鼠旷场活动次数增加(P<0.01),海马CA3区内凋亡细胞数减少(P<0.01)。结论:解郁1号可改善大鼠抑郁行为,其作用机制可能与抑制海马神经元细胞凋亡有关。

object:to explore the effect of the Chinese medicial prescription jieyu 1#,which was made in the way of tiaolipiwei,on the appptosis of hippocampus in depressed model rats. Methods:60 sd rats were ramondally divided into normal group,model group,western medicine group,and Chinese medicine group, each group were 15 rats, using the way of feeding Individually and Unpredictable chronic mild stress to copy the depressed model,apply Open-field experiment to test rats’behavior;adopt TUNEL to detect the apoptosis in the CA3 region of hippocampus. Results:the score of horizontal movement and vertical movement in model group were markedly reduced(P<0.01)。 compare to model group,The number of open-field activities in Chinese medicine group and western medicine group increased(P<0.01)。 Conclusion:jieyu 1# can improve the rats’s depressive behavior,its mechanism maybe related to inhibiting the neuronal apoptosis of hippocampus

张丽萍、武丽、张曼

医药卫生理论中医学基础医学

解郁1号抑郁症海马细胞凋亡

jieyu1#depressionhippocampusapoptosis

张丽萍,武丽,张曼.解郁1号对抑郁模型大鼠海马神经元细胞凋亡的影响[EB/OL].(2009-02-05)[2025-08-23].http://www.paper.edu.cn/releasepaper/content/200902-144.点此复制

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