经THF自氧化策略的炔酸酯脱羧级联反应

In this paper, a facile and environmentally friendly strategy has been reported.Through the auto-oxidation properties of THF, the α-functionalization of THF was achieved by using oxygen as terminal oxidant, a series of alkynoates successfully converted into corresponding tri-substituted olefin. By screening the factors involved in the reaction, such as temperature, concentration, and reaction time, the optimal reaction conditions was obtained and successfully prepared 12 tri-substituted olefin with moderate to good yield.