牙髓干细胞在牙再生中的特点和作用

In order to make up the deficiency of traditional medical treatment method, regenerative medicine as a new research field has received extensive attention in the recent years. Dental pulp stem cells(DPSCs), originating from the neural crest, become a promising source for tooth regeneration applications for their unique advantages, such as easily isolated and minimally invasive. As a kind of mesenchymal stem cells, DPSCs have the ability to differentiate in several cell phenotypes including odontogenic differentiation, vascularization and neural differentiation. To be applied in tissue engineering, DPSCs are usually combined with various scaffolds and growth factors. Based on the characterizations of DPSCs, they are considered to be a great candidate for application used in regenerative endodontic procedures and whole tooth regeneration. In this review, we have carefully described the important aspects of DPSCs and discussed the practical applications in the present studies. this paper.