金和银N-杂环卡宾簇合物的合成结构与细胞毒性研究

IGold and silver clusters, [Au2AgL2(CH3CN)2](PF6)3 (2, L = bis(N-pyridylimidazoliumyl)methane) and [Au4AgL4](PF6)5 (3), have been synthesized from [Ag3L2(CH3CN)2](PF6)3 (1) via transmetallation reactions, and their structures were determined by X-ray diffraction analysis. Complexes 1 and 2 are isostructural with each other consisting of triangular metallic rings showing weak metal-metal interaction. Complex 3 is a chain compound with the silver atom located in between two Au2 units. All the complexes are luminescent in their solid states at room temperature. The cytotoxicities of the complexes were investigated by MTT assay. The results show that all these complexes are toxic to HuH7, C6, and A375 tumor cells, and the toxicity order is 1 > 2 > 3 consistent with the silver content in these complexes.