恶性血液病患者化疗后急性药物性肝损伤的前瞻性随机对照预防研究
prospective random control study for prophylaxis of chemotherapy drug induced acute liver injury in haematological malignancy patients
目的 观察腺苷蛋氨酸和双环醇预防恶性血液病患者化疗后急性药物性肝损伤的效果。方法 采用前瞻性随机对照研究，腺苷蛋氨酸预防组为治疗组，双环醇预防组为对照组。结果 总共79例次化疗，预防失败率20.3%。腺苷蛋氨酸预防组和双环醇预防组预防失败率分别为26.8%和13.2%，两组比较无统计学意义（P=0.131）。无严重不良反应。结论 腺苷蛋氨酸和双环醇均是恶性血液病患者化疗后急性药物性肝损伤的有效、安全预防药物。
Objective To evaluate prophylactic effect of ademetionine and bicyclol tablets on chemotherapy drug induced acute liver injury in haematological malignancy patients. Methods A randomized control trial was conducted in 79 cases with haematological malignancy receiving chemotherapy for evaluating prophylactic efficacy on chemotherapy drug induced acute liver injury. Patients in therapy group were treated with bicyclol tablets and control group treated with ademetionine. Results The failure rate is 20.3%, 13.2% and 26.8% in all cases, therapy group and control group, respectively. The difference was not statistically significant between the two groups (P=0.131). No major adverse event was observed. Conclusion Both ademetionine and bicyclol tablets are effective and safe for prophylaxis of chemotherapy drug induced acute liver injury in haematological malignancy patients.
韩明哲、杨栋林、何禕、冯四洲
临床医学肿瘤学预防医学
腺苷蛋氨酸双环醇药物性肝损伤化疗恶性血液病
ademetioninebicyclol tabletsdrug induced liver injurychemotherapyhaematological malignancy
韩明哲,杨栋林,何禕,冯四洲.恶性血液病患者化疗后急性药物性肝损伤的前瞻性随机对照预防研究[EB/OL].(2012-02-20)[2025-08-02].http://www.paper.edu.cn/releasepaper/content/201202-724.点此复制
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