How does group differences in motion scrubbing affect false positives in functional connectivity studies?
How does group differences in motion scrubbing affect false positives in functional connectivity studies?
Abstract Analyzing resting state fMRI data is difficult due to a weak signal and several noise sources. Head motion is also a major problem and it is common to apply motion scrubbing, i.e. to remove time points where a subject has moved more than some pre-defined motion threshold. A problem arises if one cohort on average moves more than another, since the remaining temporal degrees of freedom are then different for the two groups. The effect of this is that the uncertainty of the functional connectivity estimates (e.g. Pearson correlations) are different for the two groups, but this is seldom modelled in resting state fMRI. We demonstrate that group differences in motion scrubbing can result in inflated false positives, depending on how the temporal auto correlation is modelled when performing the Fisher r-to-z transform.
Nichols Thomas E.、Afyouni Soroosh、Craddock Cameron、Eklund Anders
Oxford Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Population Health, University of Oxford||Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford||Department of Statistics, University of WarwickOxford Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Population Health, University of OxfordDepartment of Diagnostic Medicine, Dell Medical SchoolDivision of Medical Informatics, Department of Biomedical Engineering, Link?ping University||Division of Statistics & Machine Learning, Department of Computer and Information Science, Link?ping University||Center for Medical Image Science and Visualization (CMIV), Link?ping University
生物科学研究方法、生物科学研究技术
fMRImotion scrubbingfalse positives
Nichols Thomas E.,Afyouni Soroosh,Craddock Cameron,Eklund Anders.How does group differences in motion scrubbing affect false positives in functional connectivity studies?[EB/OL].(2025-03-28)[2025-05-04].https://www.biorxiv.org/content/10.1101/2020.02.12.944454.点此复制
评论