柳珊瑚来源真菌Aspergillus sp.中吲哚生物碱类化学成分的研究

he prenylated indole alkaloids from a marine-derived fungus Aspergillus sp. isolated from gorgonian Dichotella gemmacea which is collected from the South China Sea has been studied in order to identify bioactive compounds and explore possible biosynthetic pathways for these alkaloids. Chromatography was performed for the isolation and purification of the compounds, and their structures were determined by extensive spectroscopic data and compared with the data in literature. The bioactivities of the alkaloids were evaluated with antibacterial and brine shrimp lethality bioassay models. The results showed that eight prenylated indole alkaloids, i.e., notoamide E, notoamide D, notoamide K, notoamide I, notoamide R, notoamide F, notoamide A, and sclerotiamide, were isolated from the fungus Aspergillus sp.. The compounds notoamide A and sclerotiamide showed lethality to brine shrimps at a concentration of 5 μg/mL with lethality rates of 63.0% and 68.5%, respectively.