延胡索主要有效成分药代动力学及其相互作用研究进展

Along with the development of modern medicine, application of Chinese traditional medicine in clinical was becoming widely, so improving the study of drug-drug interactions is very important and significance for clinical. Rhizoma Corydalis was a traditional Chinese medicine, which was mainly used in the treatment of all kinds of pain, as its significant analgesic effect and low resistance, it has widely used in clinic at present. The main active ingredient of Rhizoma Corydalis was alkaloids, in which tetrahydropalmatine(THP), Protopine (PRO) and Dehydrocavidine (DHC) were active components, but the studies on interactions with CYP450s and P-gp were limited. So studies of drug-drug interactions on Rhizoma Corydalis and its active components was great significance. The author reviewed the chemical composition of Rhizoma Corydalis, and pharmacology, pharmacokinetics and in vivo drug-drug interactions of its main effective components. And puts forward the study limited of drug-drug interactions on these main activity components of Rhizoma Corydalis, and to give some suggestions for further improve the drug-drug interaction and mechanism research.