热熔法制备PCL基温敏性药物释放体系及其释药性能研究
Preparation and Drug-release Properties of Poly(?-caprolactone) Based Thermo-sensitive Drug Release Systems through Melt Blending
本文以甘油三月桂酸酯（C12）为热响应材料，双氯芬酸钠（DS）为模型药物，采用熔融共混制备了聚己内酯（PCL）基温敏性药物释放体系。通过差示扫描量热分析（DSC）、扫描电子显微镜（SEM）和亲水接触角分析表征了C12的加入对PCL/C12共混物形态结构特征的影响。研究发现，C12的加入能够改善DS的分散，调节共混物的亲水性。由于C12的疏水性，37℃时PCL/C12共混物相比于纯PCL中DS的释放更慢，而在45℃时，由于C12熔点较低（48.2℃）发生部分熔融，使得PBS缓冲液更易渗透进基体内部，从而提高DS的释放速率。结果表明，PCL/C12共混物表现出DS的温敏性释放行为，同时保持了材料的力学强度。
In this paper poly(?-caprolactone) (PCL) based thermo-sensitive drug release system was prepared through Melt blending, using glyceryl trilaurate (C12) as the thermo-responsive material. Diclofenac sodium (DS) was used as a model drug. Differential scanning calorimetry (DSC), scanning electron microscope (SEM) and water contact angle of the materials were performed to investigate the influence of C12 on the morphological properties of PCL/C12 blends. It was indicated that the addition of C12 improved the dispersion of DS, and adjusted the hydrophilic property of the blends. Due to the hydrophobicity of C12, the DS release of PCL/C12 blends was lower than that of pure PCL at 37℃. While at higher temperature (45℃), C12 was partially melted due to its low melting point (48.2℃), which improved the permeability of PBS buffer solution into the matrices, leading to a higher drug release of DS. As a result, the PCL/C12 blends exhibited a thermo-responsive DS release behavior, with the mechanical strength of the materials maintained.
陈蓉、陈霞、周虹汛、郭少云、张聪
药学生物科学研究方法、生物科学研究技术制药化学工业
温敏性药物释放聚己内酯甘油三月桂酸酯熔融共混相变
thermo-sensitive drug releasepoly(?-caprolactone)glyceryl trilauratemelt blendingphase transition
陈蓉,陈霞,周虹汛,郭少云,张聪.热熔法制备PCL基温敏性药物释放体系及其释药性能研究[EB/OL].(2017-06-07)[2025-08-11].http://www.paper.edu.cn/releasepaper/content/201701-229.点此复制
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