Personal Pharmacogenetic Testing Enhances Pharmacy Student Knowledge and Attitude Towards Precision Medicine
Personal Pharmacogenetic Testing Enhances Pharmacy Student Knowledge and Attitude Towards Precision Medicine
Abstract ObjectiveTo evaluate if pharmacy students’ participation in personal pharmacogenetic (Pgx) testing enhances their knowledge and attitude towards precision medicine (PM). MethodsFirst-year pharmacy students were offered personalized pharmacogenetic testing as a supplement to a required curricular pharmacogenomics course. Ninety-eight of 122 (80%) students completed pre- and post-course surveys assessing knowledge and attitudes regarding PM; 73 students also volunteered for personal pharmacogenetic testing of the following drug metabolizing enzymes (CYP2C19, CYP2D6, UGT1A1) and pharmacodynamics-relevant proteins (interleukin (IL)-28B & human lymphocyte antigen HLAB*5701). ResultsUsing a linear mixed effects model, we observed statistically significant improvements in 100% of knowledge and 70% of attitude-related questions for students who decided to undergo personal pharmacogenetic testing. ConclusionPersonal pharmacogenetic testing significantly enhances knowledge of and attitude related to precision medicine among PharmD trainees. This study demonstrates the feasibility and importance of educating future pharmacists by incorporating pharmacogenetic testing into professional school curricula. Funding statementThis manuscript was funded by generous contributions from the UCSF School of Pharmacy by Dean B. Joseph Guglielmo, PharmD, and by the School of Pharmacy, Department of Bioengineering and Therapeutic Sciences Department Chairs Kathleen Giacomini, PhD, and Tejal Desai, PhD.
Long-Boyle Janel、Surofchy Dalga、Oh Sam S.、Giacomini Kathy、Guglielmo B. Joseph、Burchard Esteban G、Wu Alan HB、Galanter Joshua、Guo Su、Li Megan、Xiang Pin、Desai Tejal
Department of Clinical Pharmacy, University of CaliforniaSchool of Pharmacy, University of CaliforniaDepartment of Medicine, University of CaliforniaSchool of Pharmacy, University of California||Department of Bioengineering & Therapeutic Sciences, University of CaliforniaSchool of Pharmacy, University of CaliforniaSchool of Pharmacy, University of California||Department of Bioengineering & Therapeutic Sciences, University of CaliforniaDepartment of Laboratory Medicine, University of CaliforniaDepartment of Medicine, University of California||Department of Bioengineering & Therapeutic Sciences, University of California||Department of Epidemiology and Biostatistics, University of CaliforniaSchool of Pharmacy, University of California||Department of Bioengineering & Therapeutic Sciences, University of CaliforniaDepartment of Bioengineering & Therapeutic Sciences, University of CaliforniaSchool of Pharmacy, University of CaliforniaSchool of Pharmacy, University of California||Department of Bioengineering & Therapeutic Sciences, University of California
药学医学研究方法教育
pharmacogenomicsgenotypingpharmacy curriculumpharmacogeneticspersonal pharmacogenetics
Long-Boyle Janel,Surofchy Dalga,Oh Sam S.,Giacomini Kathy,Guglielmo B. Joseph,Burchard Esteban G,Wu Alan HB,Galanter Joshua,Guo Su,Li Megan,Xiang Pin,Desai Tejal.Personal Pharmacogenetic Testing Enhances Pharmacy Student Knowledge and Attitude Towards Precision Medicine[EB/OL].(2025-03-28)[2025-05-04].https://www.biorxiv.org/content/10.1101/052043.点此复制
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