肺痹汤2号对二氧化硫染毒小鼠肺氧化损伤的干预研究

Mice were exposed to SO2 (28±2mg/m3) to induce oxidative stress; Traditional Chinese medicine (TCM) treatment group received intragastric administration of Feibitang-2 for 14 days and TCM prevention group received intragastric administration of Feibitang-2 for 28 days. Thereafter the mice were tested of the amount of content of propylene glycol (MDA) and glutathione (GSH) in lung tissues, and the impact on activity of glutathione peroxidase (GSH Px), superoxide dismutase (SOD) and catalase (CAT); pathological biopsy of lung tissues of the mice was observed. Results Comparing with control group, the amount of content of MDA in lung tissues of model group increased very significantly (P<0.001), GSH content and CAT activity decreased very significantly (P<0.001), the activity of GSH-Px, SOD decreased significantly (P<0.05). Comparing with model group, the amount of content of MDA of TCM treatment group and TCM prevention group decreased, GSH content increased, the activity of GSH-Px, SOD, and CAT recovered to some extent, though not statistically significant. Conclusions Feibitang-2 can improve the absorption of inflammatory exudation in lung tissues caused by SO2 exposure on mice; it also has a certain protective effect on oxidative stress of lung tissues caused by SO2 exposure.