对氨基苯胂酸纳米粒（p-ASAP）对仔猪生长性能和体内砷残留和排泄的影响

total of 252 weanling pigs (Duroc andrace orkshire) at an average initial body weight of 7.18?.13kg were used to investigate the effects of p-arsanilic acid nanoparticles(p-ASAP) on growth performance, retention and excretion of arsenic. The pigs were allocated to seven dietary treatments in a randomized complete block design (four replicates of nine pigs per replicate) for 35 days. The dietary treatments were: (1) basal diet, (2) basal diet + 20mg/kg p-arsanilic acid (p-ASA), (3) basal diet + 60 mg/kg p-ASA, (4) basal diet + 100 mg/kg p-ASA,(5) basal diet + 20 mg/kg p-ASAP, (6)basal diet +60 mg/kg p-ASAP, and (7) basal diet +100 mg/kg p-ASAP. Supplementation with 100 mg/kg p-ASA or with 20, 60, 100 mg/kg p-ASAP improved (P<0.05) growth performance of weanling pigs, the effects of low levels of p-ASAP (20 mg/kg feed) were similar to those of 100mg/kg p-ASA. No significant difference between 100 mg/kg p-ASA diet and 20mg/kg, 60mg/kg, or 100mg/kg p-ASAP diet was found. Both p-ASA and p-ASAP were mainly excreted through feces, ingested arsenic accumulated in all tissues of weanling pigs with the largest residual concentration found in the livers, followed by the kidneys, the skin, hair, fat, bone, skeletal muscles and finally the blood. The As content of tissues of pigs fed control diets, or 20 mg/kg p-ASA, or 20 mg/kg p-ASAP was less than 0.5礸/g. Both forms of p-ASA and p-ASAP are identical with respect to their absorption characteristics based on a dose dependent effect.