缺血前给予聚合人脐带血血红蛋白可以减轻大鼠心脏缺血再灌注损伤
Polymerized human placenta hemoglobin given before ischemia protects rat heart from ischemia reperfusion injury
目的：探讨在缺血前给予聚合人脐带血血红蛋白（PolyPHb）是否能够为缺血再灌注损伤的在体大鼠心脏提供保护作用。方法：45只SD大鼠随机分配到sham 组，control组（乳酸林格试液预处理）和PolyPHb组（用0.1gHb/kg PolyPHb预处理）。除sham组外，其余2组大鼠心脏结扎左前减支，缺血30分钟，然后开放复灌2小时。结果：与对照组相比，PolyPHb组心脏功能指标明显好转，心肌酶肌钙蛋白I和心肌组织病理学改变均有显著抑制。结论：PolyPHb预处理可以为缺血再灌注损伤的在体大鼠心脏提供明确的保护作用。
his study was to investigate whether polymerized human placenta hemoglobin (PolyPHb) given before ischemia protects in vivo rat heart function against ischemia/reperfusion (I/R) injury. Forty-five male Sprague-Dawley rats were randomly divided (n=15 per group) to sham group, control group (pretreatment with Lactated Ringer's solution) or PolyPHb group (pretreatment with 0.1gHb/kg PolyPHb). Rat hearts were subjected to 30-min ischemia by occlusion of left anterior descending, followed by 2-hr reperfusion. As compared to the control group, PolyPHb preserved cardiac function and reduced cardiac troponin-I release and histopathological changes. Therefore, PolyPHb pretreatment provided a profound cardioprotective effect on in vivo rat heart.
朱达、向许进、周荣华、杨成民、李燕燕、李涛、刘进、吴畏
基础医学
血红蛋白类携氧载体预处理心脏功能缺血再灌注损伤
hemoglobin-based oxygen carrierpretreatmentcardiac functionischemia/reperfusion injury
朱达,向许进,周荣华,杨成民,李燕燕,李涛,刘进,吴畏.缺血前给予聚合人脐带血血红蛋白可以减轻大鼠心脏缺血再灌注损伤[EB/OL].(2011-08-23)[2025-08-16].http://www.paper.edu.cn/releasepaper/content/201108-376.点此复制
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