犬24小时房颤制作及心房、心功能变化的研究

Objectives: To observe the changes of left 、right atrium size and heart function in A canine atrial fibrillation model by pacing 24 hours right atrium. Methods: Establishing atrial fibrillation model induced by a rapid right atrial pacing(600beats/min), left 、right atrium size and left ventricular ejection fraction were measured after AF 0，4，8，12，24 hours by Echocardiogram. Results: Left 、right atrium transverse diameter gradually increased, but have no significant difference(P>0.05). Left ventricular function significantly decreased 7.48% on AF 12h and 8.81％on AF 24h compared with that on AF 0h (P<0.05). Conclusions: 24 hours AF can cause atriums enlargement trendency and left ventricular ejection function impairment which probably are one of the mechanisms of atrial structure remodeling in paroxysmal atrial fibrillation.