以YAP为靶点的非小细胞肺癌研究进展

background： Lung cancer is the leading cause of cancer-related deaths on the world. and there has been little improvement in patient survival over the past decade, with non-small cell lung cancer being the most common lung cancer. present situation：Non-small cell lung cancer (NSCLC) is a common malignant tumor known to be involved in the mitogen-activated protein kinase MAPK signal transduction pathway. A large number of studies have also shown that NSCLC is closely related to Hippo-YAP (Yes associated protein 1), and YAP is an effector involved in the regulation of NSCLC pathogenesis. Aim：The process of lung cancer is complicated, and the comprehensive treatment of multiple drugs has an important impact on the prognosis of patients. It is the hope of lung cancer treatment to clarify the influence of drugs and regulatory factors on the pathogenesis of YAP in the regulation of NSCLC. This review is intended to summarize the multiple regulatory roles of YAP in NSCLC and their related mechanisms, and to find more effective treatments based on this.