miRNA相关单核苷酸多态性

miRNA-related single nucleotide polymorphisms（miR-SNP or mirSNP）are of the same category functional SNP, which could leading to deletion or disorders in gene regulation by miRNA. Whether in miRNA binding site, miRNA genes or miRNA processing genes, all of the misSNP maybe affect the regulation in target genes. MirSNPs in coding and processing genes of miRNAs exert the effect mainly by preventing the biosynthesis of miRNA. While mirSNPs in the binding regions of miRNA target genes are mainly through altering free energy or leading to function conformation disappeared, which will impact the miRNA combined with target sequence to lose original regulation. Moreover most of mirSNP are located in intergenic and intronic regions of the human genome and have important association with complex diseases including tumors. Whether in the pathogenesis research of complex diseases or finding biomarkers for diagnosis and prognosis, mirSNPs have extremely important research value.