组织芯片研究STAT3及VEGF在子宫内膜癌组织中的表达及意义
Significance and expression of VEGF and STAT3 in endometrial carcinoma by Using Tissue Chip Technique
目的：探讨信号传导与转录激活因子3（STAT3）及血管内皮生长因子（VEGF）的表达与子宫内膜癌临床病理特征之间的关系及其表达的相关性。方法：采用免疫组化的方法检测VEGF及STAT3在子宫内膜癌组织中的表达。结果：①在子宫内膜癌组织中VEGF、STAT3阳性率分别为70.2%、71.9%，与正常子宫内膜组比较，有显著差异（P＜0.05）。②癌组织中VEGF的表达与病理分级、临床分期、淋巴结转移有关（P＜0.05），STAT3的表达与病理分级、临床分期、淋巴结转移有关（P＜0.05）。③子宫内膜癌组织中VEGF与STAT3表达呈正相关（P＜0.05）。结论：VEGF和STAT3在子宫内膜癌中过表达, STAT3与子宫内膜癌的病理分级、临床分期及淋巴结转移有关，STAT3可能通过上调VEGF的表达，促进子宫内膜癌组织中新生血管的形成，可能在子宫内膜癌的发生发展中起到重要作用。
Objective：To investigate the relationship between the expression of VEGF and STAT3 and the clinicopathological factors of endometrial cancer and studied the correlations between VEGF and STAT3.Methods: Immunohistochemical staining was used for VEGF and STAT3 detection in endometrial carcinoma.Results ：①The positive rates of VEGF and STAT3 in endometrial carcinoma were 70.2%、71.9% respectively，positive rate were demonstrated significant different compared with normal endometrial tissue.② The expression of STAT3 and VEGF had relation with histological grade, TNM stage, lymph node metastasis in adenoendometrial carcinoma.The differences reached significant values(P＜0.05). The two had no relation with age.③Positive correlation was found between the expression of STAT3 and VEGF(P<0.05)in endometrial carcinoma.Conclusion：STAT3 and VEGF are over-expressed in endometrial carcinoma.The expression of STAT3 had relation with histological grade, TNM stage, lymph node metastasis in endometrial carcinoma. VEGF might be up-regulated by STAT3 to result in tumor angiogenesis．Therefore,STAT3 may play an important role in the carcinogenesis and progression of endometrial carcinoma．
董莉莳、王海琳
肿瘤学基础医学妇产科学
子宫内膜癌VEGFSTAT3免疫组织化学组织芯片
Endometrial carcinomaVEGFSTAT3Immunohistochemitryissue Chip
董莉莳,王海琳.组织芯片研究STAT3及VEGF在子宫内膜癌组织中的表达及意义[EB/OL].(2008-03-28)[2025-08-02].http://www.paper.edu.cn/releasepaper/content/200803-862.点此复制
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