NA转染在肿瘤转移中的作用

(1) First, the histochemical activity of deoxyribonuclease(DNase) is deficiency in malignant tumor cells. The activity of DNase is not elevatory in the blood plasma (serum)of malignant tumor patient.(2) Second, the content of DNA is elevatory in the blood plasma (serum)of malignant tumor patient.(3) Third, the oncogene in vitro can transform the susceptive “normal” cell. the oncogene injecting by vein can effectively induce the malignant tumor in the host.(4) Fourth, systemic administration of deoxyribonucleasesin mice prevents blood-borne metastasis to the liver of cutaneously transplanted tumor cells. Hereby put forward the HYPOTHESIS about the DNA transfection mechanism during the tumor metastasis.