静电纺三维大孔径微/纳米纤维复合支架的制备及力学性能

Preparation of the tissue engineering scaffold with three-dimensional large-pore microstructureis significanct to human tissue repair.In the present paper, the scaffold (PLA/PCL=1:1), composed of microfiber bundles and nanofibers, was prepared by electrospinning with a modified receiving device based on bath receiving and roller receiving method. The SEM results showed that the microfiber bundles were directionally arranged with a diameter of 40.83±15.40μm, and the nanofibers were randomly arranged with a diameter of 871 ± 177nm. The pore size of composite scaffold was 907.67 ± 315.64μm2, and the porosity was 91.89 ± 3.48%, which were both superior to those of the single nanofibrous scaffold. Moreover, compared with traditional electrospun scaffold, the composite scaffold possessed an improved hydrophilicity with the smaller contact angle of water (109.74 ± 3.02 ). In addition, the mechanical test results presented that the tensile strength and elongation at break in the axial direction of microfiber bundles were both superior to those in the radial direction, which was indicative of the mechanical anisotropy of electrospun three-dimensional composite scaffold. .