中老年体检人群系统免疫炎症指数和系统炎症反应指数与微量白蛋白尿的相关性研究
orrelation between Systemic Immune Inflammatory Index and Systemic Inflammatory Response Index and Microalbuminuria in Middle-aged and Elderly People who Received Health Examination
背景 微量白蛋白尿是反应肾脏早期微血管损害的敏感指标，也是心血管疾病的独立危险因素，既往研究表明长期慢性炎症在微量白蛋白尿的发生、发展中起着重要作用，但血液炎症标志物与微量白蛋白尿相关性的报道较少。目的 探讨中老年体检人群中系统免疫炎症指数（SII）和系统炎症反应指数（SIRI）与微量白蛋白尿的相关性。方法 本研究为横断面研究，选取 2023 年 4—7 月于东部战区总医院健康医学科进行健康体检的 2 105 例 40 岁以上体检者为研究对象。根据尿微量白蛋白/尿肌酐比值（UACR）将研究对象分为两组：非微量白蛋白尿组（1 857 例，UACR0.05）；微量白蛋白尿组年龄、BMI、收缩压、舒张压、空腹血糖、餐后 2 h 血糖、糖化血红蛋白、三酰甘油、同型半胱氨酸、肾小球滤过率、红细胞沉降率、SII、SIRI水平高于非微量白蛋白尿组，高密度脂蛋白胆固醇水平低于非微量白蛋白尿组（P<0.05）。线性回归分析结果显示，SII、SIRI 水平与 log UACR 均呈正相关（P<0.05）。多因素 Logistic 回归分析结果显示，校正各控制变量后，SII 水平与微量白蛋白尿发生风险呈正相关（OR=1.17，95%CI=1.01~1.35，P=0.031）；与 T1 水平患者相比，T3 水平患者微量白蛋白尿发生风险升高（OR=1.43，95%CI=1.01~2.03，P=0.046），且微量白蛋白尿发生风险随着 SII 增加呈升高趋势（P 趋势 =0.038）。校正各控制变量后，SIRI 水平与微量白蛋白尿发生风险呈正相关（OR=1.18，95%CI=1.03~1.35，P=0.019）；与 t1 水平患者相比，t3 水平患者微量白蛋白尿发生风险升高（OR=1.45，95%CI=1.01~2.09，P=0.046），且微量白蛋白尿发生风险随着 SIRI 增加呈升高趋势（P 趋势 =0.032）。结论 中老年体检人群 SII、SIRI 水平与 logUACR 及微量白蛋白尿发生风险均呈正相关。
Background Microalbuminuria is a sensitive indicator of early renal microvascular damage and an independent risk factor for cardiovascular diseases. Previous studies have shown that long-term chronic inflammation plays an important role in the occurrence and development of microalbuminuria. Howeverthe correlation between blood inflammatory markers and microalbuminuria has been less frequently reported. Objective To investigate the correlation between systemic immune inflammatory indexSIIand systemic inflammatory response indexSIRIand microalbuminuria in a middle-aged and elderly physical examination population. Methods This was a cross-sectional study in which 2105 medical examiners over the age of 40 years who underwent health check-ups from April to July 2023 at the Department of Health MedicineGeneral Hospital of the Eastern Theatre of Operations were selected as study subjects. The study subjects were divided into two groups based on the urinary microalbumin/urinary creatinine ratioUACRvaluesthe non-microalbuminuric group1 857 cases UACR0.05 ageBMIsystolic blood pressurediastolic blood pressurefasting blood glucose2 h blood glucoseglycosylated hemoglobintriglycerideshomocysteineglomerular filtration rate erythrocyte sedimentation rateSIIand SIRI levels were higher in the microalbuminuria group than those in the non-microalbuminuria groupand high density lipoprotein cholesterol level was lower than that in the non-microalbuminuria groupP<0.05. Linear regression analysis showed that the levels of SII and SIRI were positively correlated with log UACRP<0.05. The results of binary Logistic regression analysis showed that after correcting for each control variablethe level of SII was positively correlated with the risk of microalbuminuriaOR=1.17 95%CI=1.01-1.35P=0.031and T3 was positively correlated with the risk of microalbuminuria when compared to T1OR=1.43 95%CI=1.01-2.03P=0.046and the risk of microalbuminuria tended to increase with increasing SIIP =0.038. After correcting for each control variablethe level of SIRI was positively correlated with the risk of microalbuminuriaOR=1.1895%CI=1.03-1.35P=0.019t3 was positively correlated with the risk of microalbuminuria compared to t1OR=1.4595%CI=1.01~2.09P=0.046and the risk tended to increase with increasing SIRIP =0.032. Conclusion SII and SIRI levels correlated positively with both log UACRand risk of microalbuminuria in middle-aged and elderly subjects who received health examination.
周颖、金涛、倪文吉、钟勇、李丹丹、黄亚、张锐
10.12114/j.issn.1007-9572.2023.0860
内科学基础医学临床医学
白蛋白尿微量白蛋白尿系统免疫炎症指数系统炎症反应指数中老年
周颖,金涛,倪文吉,钟勇,李丹丹,黄亚,张锐.中老年体检人群系统免疫炎症指数和系统炎症反应指数与微量白蛋白尿的相关性研究[EB/OL].(2024-03-11)[2025-08-03].https://chinaxiv.org/abs/202403.00201.点此复制
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