血管壁细胞失功与移植物血管病
he dysfunction of local vascular wall cells In Chronic Allograft Vasculopathy
器官移植现已成为终末期器官疾病的常规治疗方法。近年来,随着免疫抑制剂的研究进展和临床应用,移植物急性排斥反应已得到很好的防治,但慢性排斥反应却没有明显改善,并已成为导致远期移植物功能丧失的主要原因。慢性排斥反应的主要病理特征是移植物血管病,其主要病理学改变包括移植物动脉新生内膜形成,血管中膜平滑肌细胞凋亡,血管病炎性细胞浸润以及大量细胞外基质沉积。目前研究认为,免疫因素和非免疫因素均参与移植物血管病的发生发展。而近年来,大量研究资料表明,移植物血管壁细胞失功通过募集受体衍生祖细胞而在血管新生内膜形成的发生发展中起着主导作用。本文主要对目前有关血管壁细胞失功在移植物血管病中的作用及其分子机制做一综述。
Organ transplantation has become the standard treatment for patients with end-stage organ failure. Despite the remarkable improvements of immunosuppressive agents in reducing acute rejection, chronic rejection remains the major obstacle to the long survival of allograft following transplantation. Chronic allograft vasculopathy, the common and distinctive features of chronic allograft rejection, is characterized by concentric and diffuse neointimal formation, medial apoptosis, infiltration of inflammatory cells and deposition of extracellular matrix occurred in arteries from allograft. It has been shown that both immunological factors and non-immunological factors are involved in the pathogenesis of chronic allograft vasculopathy. Recently, there is emerging evidence that the dysfunction of local vascular wall cells is responsible for the initiation and progression of neointimal formation and vascular remodeling through recruitment of progenitor cells mainly derived from recipient. This review focuses on the dysfunction of local vascular wall cells in chronic allograft vasculopathy and currents views on the possible mechanisms underlying the development of neointimal formation and vascular remodeling in allograft.
宋自芳、刘尚龙、郑启昌
医药卫生理论基础医学内科学
移植移植物血管病内皮细胞平滑肌细胞
ransplantationChronic allograft vasculopathyEndothelial cellsSmooth muscle cells
宋自芳,刘尚龙,郑启昌.血管壁细胞失功与移植物血管病[EB/OL].(2011-03-02)[2025-08-23].http://www.paper.edu.cn/releasepaper/content/201103-48.点此复制
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