不同国家地区SARS-CoV-2序列的密码子偏好性及聚类分析

\textbf{[Objective]}The codon usage bias and evolution of the SARS-CoV-2 sequences in eight countries were studied. \textbf{[Method]} Calculate the "Datum SARS-CoV-2 sequence" of the largest similar sequence group among SARS-CoV-2 genomes in eight countries, use CodonW package to analyze the codon preference of the Datum SARS-CoV-2 sequence, use MEGA-X to analyze the evolutionary relationship between Datum SARS-CoV-2 sequences in various countries. \textbf{[Result]} G+C contents are all lower than A+U contents. Among them, Canada has the lowest measure, followed by China. Commonly owned Preference: there are 19 codons in eight countries; not counting China has seven; not counting Canada has one; not counting China and Canada has one; 25 of these 28 end in A and U. Proprietary preference codon: China has 7, 6 of which end with C or G; Canada has one that ends with U. The first category is the USA, India, Chile and Belgium, and the second category is Australia, Canada, England and China. In further classification, there is uncertainty.\textbf{[Conclusion]} In order to adapt to different hosts, SARS-CoV-2 genomes are constantly mutating, co-evolution with the host, it shows situations of multi-source infections and multi-path evolution.