金欣口服液对感染RSV大鼠血清IL-6、IL-8的影响
he Effect of Jinxin Oral Liquid for the Expression of IL-6,IL-8 of SD rats'serum Infected with Respiratory Syncytial Virus
目的 观察金欣口服液对感染RSV大鼠血清中IL-6、IL-8的影响。方法 将56只SD大鼠随机分为7组，分别为正常组，模型组，金欣高、中、低剂量治疗组，预先给药组，利巴韦林治疗组。用双抗体夹心酶联免疫吸附法（ELISA）测定各组SD大鼠血清中IL-6，IL-8的水平。结果 大鼠感染RSV后血清中IL-6、IL-8水平均高于正常组(P<0.05)，金欣治疗组及利巴韦林组干预后IL-6、IL-8水平显著降低(P<0.01)。与利巴韦林组相比，金欣高剂量组、预先给药组的IL-6表达量明显降低（P<0.01）；预先给药组中，血清IL-6的水平低于中、低剂量组(P<0. 01)，而IL-8水平比高、中、低剂量均显著降低(P<0. 01)。结论 金欣口服液能降低两者的表达，且以预先给药方式更有效，推测可以预防和治疗大鼠感染RSV。
Objective To observe the effect of Jinxin Oral Liquid on the expression of rats'serum IL-6，IL-8 after RSV infection. Method 56 SD rats were divided into 7 groups randomly and equally: normal group, model group, higher, middle, lower dosages of Jinxin group by intragastric administration(ig)(HIG,MIG,LIG), ribavirin intragastric group(RIG), pre-Jinxin intragastric group(PIG). Serum levels of IL-6,IL-8 were measured by double antibody sandwich enzyme-linked immunosorbent assay (ELISA) in each group. Results After intervention, IL-6,IL-8 serum levels were significantly higher in model group (p <0.05).Compared with RIG, IL-6 levels in HIG, PIG were decreased significantly (p<0.01). The expression of IL-6 in PIG was significantly lower than that in MIG,LIG(p<0.01). And the expression of IL-8 in PIG was significantly lower than that in HIG,MIG,LIG (p<0.01). Conclusion Jinxin oral liquid can decrease serum IL-6,IL-8 expression, and it is a good way to to inhibit RSV infection more effectively by intragastric administration in advance.?????
夏晨、汪受传
医药卫生理论基础医学药学
中医儿科学呼吸道合胞病毒金欣口服液IL-6IL-8
pediatrics of traditional Chinese medicineRespiratory Syncytial VirusJinxinIL-6，IL-8
夏晨,汪受传.金欣口服液对感染RSV大鼠血清IL-6、IL-8的影响[EB/OL].(2011-01-04)[2025-08-10].http://www.paper.edu.cn/releasepaper/content/201101-162.点此复制
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