Aberrant connectivity in auditory precision encoding in schizophrenia spectrum disorder and across the continuum of psychotic-like experiences
Aberrant connectivity in auditory precision encoding in schizophrenia spectrum disorder and across the continuum of psychotic-like experiences
Abstract BackgroundThe ability to generate a precise internal model of statistical regularities is impaired in schizophrenia. Predictive coding accounts of schizophrenia suggest that psychotic symptoms may be explained by a failure to build precise beliefs or a model of the world. The precision of this model may vary with context. For example, in a noisy environment the model will be more imprecise compared to a model built in an environment with lower noise. However compelling, this idea has not yet been empirically studied in schizophrenia. Methods: In this study, 62 participants engaged in a stochastic mismatch negativity paradigm with high and low precision. We included inpatients with a schizophrenia spectrum disorder (N=20), inpatients with a psychiatric disorder but without psychosis (N=20), and healthy controls (N=22), with comparable sex ratio and age distribution. Bayesian mapping and dynamic causal modelling were employed to investigate the underlying microcircuitry of precision encoding of auditory stimuli. Results: We found strong evidence (exceedance p > 0.99) for differences in the underlying connectivity associated with precision encoding between the three groups as well as on the continuum of psychotic-like experiences assessed across all participants. Critically, we show changes in interhemispheric connectivity between the two inpatient groups, with some connections further aligning on the continuum of psychotic-like experiences. Conclusions: While our results suggest continuity in backward connectivity alterations with psychotic-like experiences regardless of diagnosis, they also point to specificity for the schizophrenia spectrum disorder group in interhemispheric connectivity alterations.
Darke Hayley、Sundram Suresh、Carter Olivia、Dzafic Ilvana、Larsen Kit Melissa、Pertile Holly、Garrido Marta I.
Melbourne School of Psychological Sciences, University of MelbourneDepartment of Psychiatry, School of Clinical Sciences, Monash University||Monash Medical Centre, Monash HealthMelbourne School of Psychological Sciences, University of MelbourneQueensland Brain Institute, The University of Queensland||Australian Research Council of Excellence for Integrative Brain Function||Melbourne School of Psychological Sciences, University of MelbourneQueensland Brain Institute, The University of Queensland||Australian Research Council of Excellence for Integrative Brain Function||Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre||Child and Adolescent Mental Health Centre, Mental Health Services Capital Region Copenhagen, University of CopenhagenDepartment of Psychiatry, School of Clinical Sciences, Monash University||Monash Medical Centre, Monash HealthQueensland Brain Institute, The University of Queensland||Australian Research Council of Excellence for Integrative Brain Function||Melbourne School of Psychological Sciences, University of Melbourne||Centre for Advanced Imaging, The University of Queensland
神经病学、精神病学医学研究方法基础医学
Posterior probability mapsDynamic causal modellingMMNschizophreniaEEGschizotypypsychosis
Darke Hayley,Sundram Suresh,Carter Olivia,Dzafic Ilvana,Larsen Kit Melissa,Pertile Holly,Garrido Marta I..Aberrant connectivity in auditory precision encoding in schizophrenia spectrum disorder and across the continuum of psychotic-like experiences[EB/OL].(2025-03-28)[2025-06-12].https://www.biorxiv.org/content/10.1101/792473.点此复制
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