Hippo信号通路在膀胱癌中的研究进展

Bladder cancer is one of the most common cancers worldwide with a high progression rate and poor prognosis. The Hippo signalling pathway is a conserved pathway that plays a crucial role in cellular proliferation, differentiation and apoptosis.Furthermore, dysregulation or malfunction of the Hippo pathway is common in various human tumours, including Bladder cancer. In this review, an overview of the Hippo pathway in Bladder cancer and other cancers is presented. We focus on recent data regarding the Hippo pathway, its network and the regulation of the downstream co-effectors YAP1/TAZ. The core components of the Hippo pathway, which induce Bladder cancer stemness acquisition, metastasis and chemoresistance, will be emphasized. Additional research on the Hippo pathway will advance our understanding of the mechanism of Bladder cancer as well as the development and progression of other cancers and may be exploited therapeutically.