吉西他滨原位温敏凝胶的制备及体内外评价

hemotherapeutic agent gemcitabine is generally used in clinic by continuous intravenous infusion due to its short half life, resulting in serious side effects. Here gemcitabine-loaded thermosensitive hydrogel was prepared and evaluated with respect to both in vitro drug release and rheology and in vivo anti-tumor efficacy and systemic toxicity. Results show that gemcitabine-loaded thermosensitive hydrogel can release drug at a slow and steady rate, improved in vivo tumor growth inhibition and alleviated systemic toxicity,indicating good potential of thermosensitive hydrogel for sustained-release administration of gemcitabine for local chemotherapy.