Aberrant functional brain network organization is associated with relapse during 1-year follow-up in alcohol-dependent patients
Aberrant functional brain network organization is associated with relapse during 1-year follow-up in alcohol-dependent patients
Abstract Alcohol dependence (AD) is a debilitating disease associated with high relapse rates even after long periods of abstinence. Thus, elucidating neurobiological substrates of relapse risk is fundamental for the development of novel targeted interventions that could promote long-lasting abstinence. In the present study, we analyzed resting-state functional magnetic resonance imaging (rsfMRI) data from a sample of recently detoxified AD patients (n = 93) who were followed-up for 12 months after rsfMRI assessment. Specifically, we employed graph theoretic analyses to compare functional brain network topology and functional connectivity between future relapsers (REL, n = 59), future abstainers (ABS, n = 28) and age and gender matched controls (CON, n = 83). Our results suggest increased whole-brain network segregation, decreased global network integration and overall blunted connectivity strength in REL compared to CON. Conversely, we found evidence for a comparable network architecture in ABS relative to CON. At the nodal level, REL exhibited decreased integration and decoupling between multiple brain systems compared to CON, encompassing regions associated with higher-order executive functions, sensory and reward processing. Among AD patients, increased coupling between nodes implicated in reward valuation and salience attribution constitutes a particular risk factor for future relapse. Importantly, aberrant network organization in REL was consistently associated with shorter abstinence duration during follow-up, portending to a putative neural signature of relapse risk in AD. Future research should further evaluate the potential diagnostic value of the identified changes in network topology and functional connectivity for relapse prediction at the individual subject level.
Heinz Andreas、Walter Henrik、Kruschwitz Johann D.、Zimmermann Ulrich S.、Reinhardt Pablo、Marxen Michael、Bzdok Danilo、Friedel Eva、Garbusow Maria、B?hmer Justin、Smolka Michael N.
Department of Psychiatry and Psychotherapy CCM, Charit¨| ¨C Universit?tsmedizin Berlin, Corporate Member of Freie Universit?t Berlin, Humboldt-Universit?t zu Berlin, and Berlin Institute of HealthDepartment of Psychiatry and Psychotherapy CCM, Charit¨| ¨C Universit?tsmedizin Berlin, Corporate Member of Freie Universit?t Berlin, Humboldt-Universit?t zu Berlin, and Berlin Institute of Health||Collaborative Research Centre (SFB 940) ?°Volition and Cognitive Control?±, Technische Universit?t DresdenDepartment of Psychiatry and Psychotherapy CCM, Charit¨| ¨C Universit?tsmedizin Berlin, Corporate Member of Freie Universit?t Berlin, Humboldt-Universit?t zu Berlin, and Berlin Institute of Health||Collaborative Research Centre (SFB 940) ?°Volition and Cognitive Control?±, Technische Universit?t DresdenDepartment of Psychiatry and Psychotherapy, Technische Universit?t Dresden||Department of Addiction Medicine and Psychotherapy, kbo-Isar-Amper-Klinikum M¨1nchen-OstDepartment of Psychiatry and Psychotherapy CCM, Charit¨| ¨C Universit?tsmedizin Berlin, Corporate Member of Freie Universit?t Berlin, Humboldt-Universit?t zu Berlin, and Berlin Institute of HealthDepartment of Psychiatry and Psychotherapy, Technische Universit?t Dresden||Collaborative Research Centre (SFB 940) ?°Volition and Cognitive Control?±, Technische Universit?t DresdenDepartment of Biomedical Engineering, Faculty of Medicine, McConnell Brain Imaging Centre (BIC), Montreal Neurological Institute (MNI), McGill University||Mila - Quebec Artificial Intelligence InstituteDepartment of Psychiatry and Psychotherapy CCM, Charit¨| ¨C Universit?tsmedizin Berlin, Corporate Member of Freie Universit?t Berlin, Humboldt-Universit?t zu Berlin, and Berlin Institute of HealthDepartment of Psychiatry and Psychotherapy CCM, Charit¨| ¨C Universit?tsmedizin Berlin, Corporate Member of Freie Universit?t Berlin, Humboldt-Universit?t zu Berlin, and Berlin Institute of HealthDepartment of Psychiatry and Psychotherapy CCM, Charit¨| ¨C Universit?tsmedizin Berlin, Corporate Member of Freie Universit?t Berlin, Humboldt-Universit?t zu Berlin, and Berlin Institute of HealthDepartment of Psychiatry and Psychotherapy, Technische Universit?t Dresden||Collaborative Research Centre (SFB 940) ?°Volition and Cognitive Control?±, Technische Universit?t Dresden
神经病学、精神病学医学研究方法基础医学
Alcohol dependencealcoholismalcohol use disorderconnectomicsfunctional connectivitygraph theoryrelapseresting-state fMRI
Heinz Andreas,Walter Henrik,Kruschwitz Johann D.,Zimmermann Ulrich S.,Reinhardt Pablo,Marxen Michael,Bzdok Danilo,Friedel Eva,Garbusow Maria,B?hmer Justin,Smolka Michael N..Aberrant functional brain network organization is associated with relapse during 1-year follow-up in alcohol-dependent patients[EB/OL].(2025-03-28)[2025-04-30].https://www.biorxiv.org/content/10.1101/2023.06.01.543210.点此复制
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