氟化铈钠纳米闪烁晶体用于肿瘤声动力治疗

Objective] To develop a novel highly effective and safe sonosensitizer for tumor sonodynamic therapy (Sonodynamic therapy, SDT) to overcome the limitations of traditional tumor treatment. [Methods] A series of scintillators were synthesized and selected by high-temperature thermal decomposition to verify the efficiency of subsequent acoustic sensitization and to explore the effects of this SCNTs-based SDT at both in vitro and in vivo levels.[Results]Scintillating nanodots (ScNDs) with uniform morphology were synthesized. ScND-PEG selected based on acoustic sensitization efficiency can further improve the production rate of Reactive oxygen species (ROS) under the action of Ultrasound, US by consuming Glutathione (GSH). Excellent SDT effects were demonstrated at the cellular and animal levels. [Conclusion]The results of this study show that the ScND-PEG has a good SDT effect, and can play a new role in tumor treatment and even in other diseases in the future.