血清同型半胱氨酸测定在糖尿病肾病中的临床意义

Objective To study the serum homocysteine (Hcy) level in diabetic nephropathy patients and the its correlation ofthe inflammatory factors. Methods From February 2012 to August 2012, a total of 160 patients with type 2 diabeticnephropathy were selected in our hospital, according to the urinary albumin excretion rate and serum creatinine level, which isdivided into diabetes mellitus group (DM group), early diabetic nephropathy (EDN) group, diabetic nephropathy group(CDN) and renal failure (CRF) group, 40 cases of healthy physical examination as the control group, comparing the patientsHcy level and their biochemical index in the five group patients, to analyze the correlation between the Hcy level and theinflammatory factor, such as IL-6, IL-1 TNF- and hs CRP. Results GLUHb A1cUREACrTPALBTCH and TG in the fivegroup patients had no significant difference (P<0.01), the five patients of Hcy comparative differences were statisticallysignificant (F=27.452, P<0.01), the inflammation indicator in the five patients, including hs CRP, TNF-, IL-1 and IL-6comparison had significant difference (P<0.01), the serum Hcy levels had significant positive correlation with hs CRP (r=0.624,P<0.01), the serum Hcy levels had significant positive correlation with TNF- (r=0.557, P<0.01), the serum Hcy levels hadsignificant positive correlation with IL-1 (r=0.568, P<0.01), serum Hcy levels had significant positive correlation with IL-6 (r=0.417, P=0.017). Conclusion Hcy plays a great important role in the progression of diabetic nephropathy, it can be used as theimportant indexes for evaluation of renal vascular injury and disease progression in DN patients, and has significant positivecorrelation with hs CRP, IL-1, IL 6 and TNF-.