基于多组学的老年衰弱人群生物标志物研究进展
Advances in studies on multi-omics-based biomarkers of frailty in the elderly
老年衰弱（frailty）是指老年人以肌少症为基本特征的全身多系统构成的稳态网体系受损，导致生理储备下降、抗打击能力减退及应激后恢复能力下降的非特异性状态，衰弱的早期诊断对于帮助老年人恢复健康具有重要价值。近年来，随着组学研究的技术进步，为发现早期衰弱的潜在特异、稳定和可靠的相关生物标志物提供了新的途径。本文整理分析相关研究后，从基因组学、转录组学、蛋白质组学、代谢组学的角度回顾血样中衰弱生物标志物研究进展，有助于评估衰弱风险，探索衰弱的潜在机制，制定针对性干预措施，助力健康老龄化。
医学研究方法基础医学生物科学研究方法、生物科学研究技术
衰弱早期衰弱多组学生物标志物
徐婷, 季明辉, 陈一萌, 高瑜, 朱涵菲, 丁玲玉, 许勤.基于多组学的老年衰弱人群生物标志物研究进展[EB/OL].(2022-10-28)[2025-11-07].https://chinaxiv.org/abs/202211.00053.点此复制
Early diagnosis of frailty is of great value in helping elderly to regain their health, as it is a non-specific state of reduced physiological reserve, reduced resistance to shock and reduced ability to recover from stress. In recent years, technological advances in histological research have provided new avenues for the discovery of potentially specific, stable and reliable appropriate biomarkers of pre-frailty. After gathering and analyzing relevant studies, this paper reviews advances in research on biomarkers of pre-frailty in blood samples from the perspective of epigenomics, transcriptomics, proteomics and metabolomics, which can assist in assessing the risk of frailty, exploring potential mechanisms of frailty and developing targeted interventions to support healthy aging.
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