PDE3抑制剂对卵母细胞成熟作用的研究进展

cAMP is essential in regulating ovulation in oocytes and cumulus cells which is regulated by phosphodiesterase （PDE）. PDE3 is the key regulator in mammalian oocytes. PDE3 inhibitors can effectively block meiosis in oocytes, which results in two main effects, on one hand it might alleviate asynchrony by allowing time for completion of cytoplasmic maturity; on the other hand by supressing oocyte maturation during ovalution it can be used as potential contraceptives. In this review, research progress of PDE3 inhibitors in oocyte maturation is summarized,also the potential side effects are considered.