羟基磷灰石接枝壳聚糖表面改性及其复合水凝胶的生物相容性

For further improvement of the compatibility between chitosan(CS) and hydroxyapatite (HA), surface modification of HA was carried out with CS to prepare hydroxyapatite-grafted-chitosan (HAg-CS) The results of FT-IR, TGA and XRD show that CS was successfully grafted onto HA surface, SEM observation showed that the dispersity of HA-g-CS in the CS matrix was significantly improved, and the CS/HA-g-CS hydrogel exhibited much more better compression performance than that of the CS/HA. The biocompatibility evaluation showed that the CS/HA-g-CS composite hydrogel showed no cytotoxicity and implantation safety in vitro according with the requirement of national standards, and was expected to be served as a potential scaffold material applied in tissue engineering.