活血化瘀法对萎缩性胃炎癌前病变大鼠胃粘膜形态学的影响

Objective : To observe the influence of three therapies of Activating the blood and resolve blood stasis on morphological changes of gastric mucosa in rats with precancerous lesion of CAG. Methods: Replicate the rats model by methods of phlorus spring insertion and hot paste. The rats model were randomly divided into five groups: the normal control group ,spontaneous recovery group, Activating the blood and resolve blood stasis group,Regulate Qi and Activating the blood group, Supplementing Qi and Activating blood group. Results: In the spontaneous recovery group the result of the light microscope showed that the gastric mucosa was atrophied and thinner,the glands was getting less,the various dysplasia were occurred.After the treating of the therapies of Supplementing Qi and Activating blood and Activating the blood and resolve blood stasis the inflammation of gastric mucosa and dysplasia were all relieved or disappeared. The Post-treatment the scores of Pathomorphology in Supplementing Qi and Activating blood and Activating the blood and resolve blood stasis groups was significantly reduced than the spontaneous recovery group（P〈0.05 or P〈0.01）;Conclusions: The therapies of Supplementing Qi and Activating blood and Activating the blood and resolve blood stasis may have a better interrupt and reversal effect on the on precancerous lesion of CAG, such as gastric mucosa atrophy and dysplasia.