eRF3b-36片段对化学诱导的小鼠肝癌的抑制作用研究

Objective To study the inhibitory effect of eRF3b-36 fragment on chemically induced hepatocarcinoma in mice and its mechanism. Methods The mice hepatocarcinoma model was induced by DEN+CCL4+ethanol, the effects of different doses of eRF3b-36 fragment on the development of liver tumors, the pathological changes of liver tissues, serum liver function indexes, the relative mRNA expression levels of hepatocarcinoma biomarkers and cell proliferation related factor were observed. Results The eRF3b-36 fragment reduced the number of liver tumors, improved the pathological changes of liver tissues, and reduced the serum ALT and AST levels, the relative mRNA expression levels of hepatocarcinoma biomarkers AFP, GPC3 and cell proliferation related factors Ki-67, Myc, Cyclin D1, Cyclin E1. Conclusion eRF3b-36 fragment can inhibit chemically induced hepatocarcinoma in mice and its mechanism may be related to the inhibition of cell proliferation.