Baseline hypocapnia is associated with intubation in COVID-19 diagnosed patients
Baseline hypocapnia is associated with intubation in COVID-19 diagnosed patients
ABSTRACT IntroductionHypocapnia may be one of the several factors predefining the need for intubation of patients needing hospitalization for COVID-19 pneumonia. MethodsA retrospective evaluation of patient files hospitalized for COVID-19 pneumonia from October 2020 until January 2021. Univariate and multivariate regression was used, as well as a multinomial regression to account for multiple endpoints (discharge, intubation, death). ResultsHypocapnia was strongly associated with intubation (OR: 0.86, 95% CI: 0.76, 0.97). Additionally, last pCO2 (OR: 1.08, 95% CI: 1.01, 1.16), baseline FiO2 (OR: 1.05, 95% CI: 1.03, 1.07) as well as last FiO2 (OR: 1.21, 95% CI: 1.11, 1.46), total severity score on admission (OR: 1.18, 95% CI: 1.03, 1.37) and last pO2 (OR: 0.89, 95% CI: 0.85, 0.92) were found to have a significant impact on intubation. Incorporation of deceased patients withheld the negative association with pCO2 levels (OR: 0.88, 95% CI: 0.78, 0.98). ConclusionThe dissociation between respiratory failure and a clinically comfortable patient is partly due to decreased carbon dioxide levels and clinicians should bare it in mind when handling patients with COVID-19 pneumonia. Hypocapnia seems to be a determinant factor of intubation in patients with COVID-19 pneumonia in this study.
Apostolopoulou Martha、Evangeliou Alexandros P.、Manganari Evangelia、Parisi Christiana、Kotronis Georgios、Gounidis Athanasios、Kourtidis Michalis、Apostolidou-Kiouti Fani、Kloura Christina
Department of Internal Medicine, Agios Pavlos General Hospital of ThessalonikiDepartment of Internal Medicine, Agios Pavlos General Hospital of ThessalonikiDepartment of Internal Medicine, Agios Pavlos General Hospital of ThessalonikiDepartment of Internal Medicine, Agios Pavlos General Hospital of ThessalonikiDepartment of Internal Medicine, Agios Pavlos General Hospital of ThessalonikiDepartment of Internal Medicine, Agios Pavlos General Hospital of ThessalonikiDepartment of Internal Medicine, Agios Pavlos General Hospital of ThessalonikiBiomedical Statistics Unit, Medical Faculty, Aristotle University of ThessalonikiDepartment of Internal Medicine, Agios Pavlos General Hospital of Thessaloniki
临床医学基础医学医学研究方法
COVID-19HypocapniaIntubation
Apostolopoulou Martha,Evangeliou Alexandros P.,Manganari Evangelia,Parisi Christiana,Kotronis Georgios,Gounidis Athanasios,Kourtidis Michalis,Apostolidou-Kiouti Fani,Kloura Christina.Baseline hypocapnia is associated with intubation in COVID-19 diagnosed patients[EB/OL].(2025-03-28)[2025-05-28].https://www.medrxiv.org/content/10.1101/2021.11.19.21266581.点此复制
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