Lipid Lowering Oxopropanylindole Hydrazone Derivatives with Anti-oxidant and Anti-hyperglycemic Activity
Lipid Lowering Oxopropanylindole Hydrazone Derivatives with Anti-oxidant and Anti-hyperglycemic Activity
Abstract A series of substituted oxopropanylindole hydrazone derivatives was synthesized and evaluated for anti-oxidant and anti-dyslipidemic activity. Among these 12 compounds the three compounds 6c, 7b and 7d showed good anti-oxidant activity and the compound 6c attenuataed LDL oxidation by 32%. The compounds 6c and 7d also showed good anti-dyslipidemic activity by reducing serum levels of total cholesterol (TC), phospholipids (PL) and triglycerides (TG). These two compounds were further evaluated for anti-adipogenic and anti-hyperglycemic activity, where 6c was found most active compound with 44% reduction in lipid accumulation and 20.5% and 24.3% reduction in blood glucose at 5h and 24h respectively, as compared to standard drug metformin.
K.Saxena Anil、Gupta Amit K.、Sonkar Ravi、Saxena Mridula、Jain Sudha、Varshney Kanika、Mishra Akanksha、Gaikwad Anil、Bhatia Geetika、Srivastava Arvind Kumar、Varshney Salil
Medicinal & Process Chemistry Division, Central Drug Research InstituteDepartmentof Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center at HoustonBiochemistry DivisionPharmacology Division, Central Drug Research InstituteDepartment of Chemistry, Lucknow UniversityMedicinal & Process Chemistry Division, Central Drug Research InstituteBiochemistry DivisionPharmacology Division, Central Drug Research InstituteBiochemistry DivisionBiochemistry DivisionPharmacology Division, Central Drug Research Institute
药学生物化学生物科学研究方法、生物科学研究技术
Hydrazone derivativesAnti-oxidantAnti-dyslipidemicAtherosclerosis
K.Saxena Anil,Gupta Amit K.,Sonkar Ravi,Saxena Mridula,Jain Sudha,Varshney Kanika,Mishra Akanksha,Gaikwad Anil,Bhatia Geetika,Srivastava Arvind Kumar,Varshney Salil.Lipid Lowering Oxopropanylindole Hydrazone Derivatives with Anti-oxidant and Anti-hyperglycemic Activity[EB/OL].(2025-03-28)[2025-05-23].https://www.biorxiv.org/content/10.1101/477315.点此复制
评论