同源框基因NKX3.1在人前列腺组织和前列腺癌中表达的研究

KX3.1 is a newly found,androgen-regulated prostate- specific homeobox gene.It may play an important role in the development,differentiation and carcinogenesis of prostate.This study aims to explore the expression profile of NKX3.1 in prostate tissures of different ages and in benign and malignant prostate tissures. Methods Immunohistochemistry were carried out to detect the the expression profile of NKX3.1 in prostate tissures of different ages, and prostate cancer specimens . Results There were no significant difference of the expression of NKX3.1 between the adult and old prostate tissures,while both of which were stronger than the fetal prostate tissures.The expression of NKX3.1 in a total of 32 prostate cancer specimens are stronger than that of other benign prostate tissures.And the expression of NKX3.1 in low differentiation specimens were stronger than that of middle and high differentiation specimens.