龙虾壳红色素对D-半乳糖衰老模型小鼠学习记忆及脑组织抗氧化能力的影响
he Effects of Astaxanthin on Learning Ability and the Oxidative Stress in Brain of Aging Mice Induced by D-galactose
目的 观察龙虾壳红色素对D-半乳糖衰老模型小鼠的影响。方法 建立D-半乳糖致小鼠衰老模型，通过Y迷宫实验观察D-半乳糖衰老模型小鼠学习记忆能力,采用黄嘌呤氧化酶法、TBA比色法测定大脑SOD活性和MDA含量活性，Sohal法测定小鼠大脑组织中脂褐质(LF) 含量，双波长薄层扫描仪测定全脑谷氨酸(L-glu)的含量。观察小鼠服用龙虾壳红色素提取物后上述指标的变化。结果 与D-半乳糖模型组相比,龙虾壳红色素中、高剂量可提高衰老模型小鼠的学习记忆能力(P<0．05)；龙虾壳红色素中、高剂量可增加D-半乳糖所致衰老模型小鼠大脑SOD活性、降低MDA、LF含量(P<0．05)；虾红素高剂量可抑制谷氨酸含量的增加(P<0．05)。结论 龙虾壳红色素能有效改善D-半乳糖致衰老小鼠空间学习记忆能力及脑组织的抗氧化能力，从而达到延缓脑衰老的作用。
Objective To study the effect of Astaxanthin on the Oxidative Stress in Brain of Aging Mice Induced by D-galactose．Methods With the model of aging mice induced by D-gal ，the learning memory ability of mice was measured by using Y-maze，and the contents of SOD、MDA、Lipofuscin and L-glutamate in the cerebrums were determined, the mice treated with Astaxanthin were observed．Results In D-gal+ Astaxanthin (middle or high doses)groups，the abilities of learning-memory of aging mice were remarkably improved ,the activities of SOD increased and the MDA、Lipofuscin and L-glutamate content decreasd clearly in the cerebrums of mice, when compared with D-gal model group(P<0.05) ．Conclusions Astaxanthin can ameliorate aging of mice induced by D-gal．
孙晓雷、汤伟、周鸣鸣、张洁
基础医学生物化学生理学
虾红素-半乳糖抗氧化
staxanthin-galactoseantioxidant
孙晓雷,汤伟,周鸣鸣,张洁.龙虾壳红色素对D-半乳糖衰老模型小鼠学习记忆及脑组织抗氧化能力的影响[EB/OL].(2013-10-15)[2025-08-16].http://www.paper.edu.cn/releasepaper/content/201310-127.点此复制
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